Assessment of serum Sclerostin level and its relationship to coronary calcifications in chronic kidney disease patients

Background: In individuals with chronic kidney disease (CKD) or end-stage renal disease, one of the leading causes cardiovascular death is calcification (CVC) (ESRD). Serum sclerostin levels were shown to be elevated in CKD. illness patients are a reliable predictor low-turnover bone according new research. Bone metabolism and osseous both regulated by several these characteristics. The purpose this study was determine relationship between CKD patients' serum coronary calcifications. Methods subjects: GFR less than 60 ml/min who on regular hemodialysis, as well 20 not hemodialysis control group compared case comparative Results: Hemodialysis-dependent have significantly higher CAC scores (agatston scores) calcific plaque non-hemodialysis-dependent patients, those been for more year it year. They also Sclerostin healthy subjects. A positive MSCT Scan Coronaries associated risk developing artery (CAD). Patients score units) that suggest vascular had levels.A high blood level linked an increased CAC.